Figure 5.

ACAT-1 Inhibition Increased the Targeting MSLN CAR-T Cell Potency against MSLN-BxPC-3-Luci Xenografts In Vivo

(A and B) Tumor bioluminescence images of mice transplanted with MSLN-BxPC-3-Luci tumor cells at the indicated time points. (C and D) Comparison of the tumor bioluminescence intensities between the CAR-T and control groups. Bioluminescence imaging showed that sustained tumor regression was observed for CAR-T-1847 cells compared to the Blank and CAR-T-2598 groups at day 33 (P < 0.05). (E and F) Comparison of the tumor volume between the CAR-T and control groups. CAR-T-1847 group showed a significantly reduced tumor volume compared to that of the CAR-T-2598 group (120.29 ± 98.04 mm³ vs. 379.18 ± 63.19 mm³; P < 0.05).