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. 2020 Mar 7;6(3):e03526. doi: 10.1016/j.heliyon.2020.e03526

Figure 1.

Figure 1

Schematic diagram for T cell activation and mechanism of IP3 activation. (A) Schematic diagram of the mechanism of Ca2+ dynamics in T-cells. (B) IP3 activation pathway. (C) The model of IP3R/channel subunit [78]. Each subunit represents an IP3 binding site, activating and inactivating Ca2+ binding site. Each state is labeled Xikj, where i (IP3 binding site), j (activating Ca2+ binding site) and k (inactivating Ca2+ binding site) are equal to 0 (unoccupied binding site) or 1 (occupied binding site) [78].