Skip to main content
. 2020 Mar 7;6(3):e03526. doi: 10.1016/j.heliyon.2020.e03526

Figure 11.

Figure 11

Block of membrane currents can affect T lymphocyte activation. Agonist was applied from 200 s to 1200 s. [Ca2+]o was held at 2,0 mM throughout the simulation. (A) [Ca2+]cyt transients are reduced with block of IK(Ca) (green) compared to control (black). Under the current channel expression levels, block of ICaL (blue) and IK (tan) have little effect on the [Ca2+]cyt transient. (C) NFAT translocation to the nucleus is attenuated with block of IK(Ca) (green) compared to control (black). Block of ICaL (blue) and IK (tan) have only a small effect on NFAT translocation to the nucleus. (B) [Ca2+]cyt transients are reduced with block of ITRPC3 (dark green) compared to control (black). Under the current channel expression levels, block of ITRPM4 (light blue) and INa (fuschia) have little effect on the [Ca2+]cyt transient. Note that increasing ITRPM4 decreases the [Ca2+]cyt transient. (D) NFAT translocation to the nucleus is attenuated with block of ITRPC3 (dark green) compared to control (black). Block of INa (light blue) and ITRPM4 (fuchsia) have only a small effect on NFAT translocation to the nucleus.