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. 2020 Mar 7;6(3):e03526. doi: 10.1016/j.heliyon.2020.e03526

Figure 2.

Figure 2

Simulated Ca2+ transients with [Ca2+]o = 2.0mM from 420s to 800s and agonist application after 60s. (A) The simulated cytosolic calcium concentration. (B) Subspace calcium transients are slightly higher than the cytosolic calcium concentration. (C) Mitochondrial Ca2+ concentration is higher than both [Ca2+]cyt and [Ca2+]ss. (D) Initial intracellular ER store calcium concentration depletion as Ca2+ is released from the ER store, and an additional decrease in [Ca2+]ER after removal of extracellular calcium. (E) A comparison of PMCA states corresponds to Ca2+ transient from unmodulated (red line) to modulated (black line) PMCA with [Ca2+]o set to 2.0 mM from 420 s to 800 s.