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The model predicts the Ca2+ concentrations in the ER, mitochondria, and subspace. (A) The changes in ER Ca2+ concentration for the four cases from Figure 4: control (black), disabled mitochondrial Ca2+ uptake (red), blocked SERCA pump (green), and disabled mitochondria and SERCA (blue). (B) The mitochondria activity for four cases. (C) The changes in subspace Ca2+ concentrations for all four cases.
