Figure 8.

Transcription factors activation corresponds to the Ca²⁺ transient. (A) Transients in [Ca²⁺]_cyt are induced by agonist activation with 0.0 mM [Ca²⁺]_o. Activation of NFAT from resting state corresponds to the top panel. (B) Simulation of Ca²⁺ transition in the cytoplasm ([Ca²⁺]_cyt) is induced by agonist and [Ca²⁺]_ot was set to 2.0 mM for 1000 s. (C)–(D). Calculated active NFAT from the resting state corresponds to the Ca²⁺ transient from the top panels. (E)–(F) Simulated active ΝFκΒ from the resting state corresponds to the Ca²⁺ transient from the top panels. (G)–(H) Calculated percent active JNK from the resting state corresponds to the Ca²⁺ transient from the top panels.