Table 2.

Ca²⁺ Regulatory Mechanism Parameters and Binding Constants of IP₃ receptor.

Parameters	Definition	Values	Reference
v1	Maximum IP3 receptor flux	90 s−1	Rescaled from [78]
a1	IP3 binding constant	400 μM−1 s−1	[78]
a2	Ca2+ inhibitory receptor binding constant	0.2 μM−1 s−1	[78]
a3	IP3 binding constant	400 μM−1 s−1	[78]
a4	Ca2+ Inhibitory receptor binding constant	0.2 μM−1 s−1	[78]
a5	Ca2+activation receptor binding constant	20.0 μM−1 s−1	[78]
d1	IP3 dissociation constant	0.13 μM	[78]
d2	Ca2+ Inhibitory receptor dissociation constant	1.049 μM	[78]
d3	IP3 dissociation constant	0.9434 μM	[78]
d4	Ca2+ Inhibitory receptor dissociation constant	0.1445 μM	[78]
d5	Ca2+activation receptor dissociation constant	82.34 nM	[78]
vSERCA	Maximal velocity for SR Ca2+ ATPase	1.0 μM s−1	[2, 78]
Kserca	Ca2+ dissociation constant for SR Ca2+ ATPase	0.1 μM	[2, 78]
τsscyt	Transfer time constant between subspace and cytosol	0.5 s	Estimated