Table 5.

Parameters of I_CRAC channel and PMCA pump.

Parameters	Definition	Values	Reference
Vu	Unmodulated PMCA velocity	1.54×106 s−1	[26]
Ku	Dissociation constant for Ca2+ stimulation of unmodulated PMCA	303.0 nM	[26]
Vm	Modulated PMCA velocity	2.20×106 s−1	[26]
Km	Dissociation constant for Ca2+ stimulation of modulated PMCA	140.0 nM	[26]
Kinact	Dissociation constant for ORAI1 Ca2+ inhibition by CRACR2A	0.8 μM	Estimated
Kcc	Dissociation constant for time constant for ORAI1 inhibition by calmodulin	2.0 μM	Estimated
Kact	Dissociation constant for ER Ca2+ inhibition	200.0 μM	Estimated
τinact	JCRAC inactivation time constant	40 s	[10]
τact	JCRAC activation time constant	3 s	[93]
αSS	Subspace Ca2+ activity coefficient	1.0	Fit to [26]
αo	Extracellular Ca2+ activity coefficient	0.341	Fit to [26]
PCRAC	CRAC permeability to Ca2+	2.8 × 10−10 cm3/s	Estimated