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. 2020 Feb 27;2020:2786139. doi: 10.1155/2020/2786139

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Copyright © 2020 Fang Su et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

CIRBP reversed iAβ-induced electrophysiological changes that are responsible for neuronal toxicity. (a, b) Resting membrane potentials (RMP) (a) and membrane capacitance (b) were recorded among different groups. ^∗∗p < 0.01vs. Ad-Con, ^#p < 0.05vs. Ad-Con+iAβ. (c) Typical recordings of whole-cell K⁺ current in the Ad-Con, Ad-Con+iAβ, and Ad-CRIPB+iAβ groups by depolarizing the membrane from -70 mV to +70 mV from a holding potential at -70 mV with 10 mV increasing steps. (d) Current-voltage relationship of the peak K⁺ current density. ^∗∗p < 0.01vs. Ad-Con. (e) Voltage-dependent activation curve of K⁺ current showing there was no difference among different groups.