Table 3.
The adjusted hazardous ratios and 95% confidence interval for the risk of diabetes across red blood cell distribution width (RDW) quartile groups: sensitivity analyses.
| Baseline RDW quartile groups (%) | Each percent of RDW | p trend | |||||
|---|---|---|---|---|---|---|---|
| Q1 ≤12.2 |
Q2 12.3~12.6 |
Q3 12.7~13.1 |
Q4 ≥13.2 |
||||
| Sensitivity-1 | Sample | 4,389 | 3,448 | 3,925 | 4,245 | — | — |
| Case | 566 | 486 | 639 | 746 | — | — | |
| Model | 1.00 (ref) | 1.04 (0.91, 1.18) | 1.18 (1.05, 1.34) | 1.32 (1.16, 1.5) | 1.23 (1.13, 1.35) | <0.001 | |
| Sensitivity-2 | Sample | 3,574 | 2,768 | 3,128 | 3,383 | — | — |
| Case | 439 | 349 | 483 | 539 | — | — | |
| Model | 1.00 (ref) | 1.01 (0.87, 1.18) | 1.21 (1.05, 1.39) | 1.33 (1.14, 1.54) | 1.24 (1.12, 1.38) | <0.001 | |
| Sensitivity-3 | Sample | 2,689 | 1,981 | 2,318 | 2,692 | — | — |
| Case | 321 | 243 | 328 | 398 | — | — | |
| Model | 1.00 (ref) | 1.01 (0.84, 1.22) | 1.15 (0.97, 1.37) | 1.33 (1.11, 1.6) | 1.25 (1.1, 1.41) | <0.001 | |
| Sensitivity-4 | Sample | 4,564 | 3,606 | 4,173 | 4,546 | — | — |
| Case | 617 | 528 | 712 | 830 | — | — | |
| Model | 1.00 (ref) | 1.03 (0.97, 1.17) | 1.17 (1.04, 1.32) | 1.31 (1.16, 1.48) | 1.23 (1.13, 1.34) | <0.001 | |
| Sensitivity-5 | Sample | 4,568 | 3,607 | 4,183 | 4,201 | — | — |
| Case | 616 | 529 | 714 | 789 | — | — | |
| Model | 1.00 (ref) | 1.03 (0.91, 1.17) | 1.16 (1.03, 1.31) | 1.31 (1.16, 1.48) | 1.23 (1.13, 1.33) | <0.001 | |
Note: Sensitivity-1: excluding participants whose age ≥ 65 y (n = 964). Sensitivity-2: excluding participants whose systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 80 mmHg (n = 4,118). Sensitivity-3: excluding participants with overweight and obesity (n = 7,291). Sensitivity-4: excluding participants with decreased eGFR (n = 82). Sensitivity-5: excluding participants with anemia (n = 412). Adjusting for age (y), sex, BMI (kg/m2), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low-density lipoprotein cholesterol (mmol/L), high-density lipoprotein cholesterol (mmol/L), eGFR (mL/min per 1.73 m2), alanine transferase (U/L), aspartate transferase (U/L), hemoglobin (g/L), hematocrit (109/L), red blood cell count (1012/L), white blood cell count (109/L), high-sensitivity C-reactive protein (mg/L), fasting blood glucose (mmol/L), and glycated hemoglobin A1c (%).