Fig. 1.

Image processing framework. Grey matter-white matter and grey matter-CSF cortical surfaces were extracted from the T1-weighted image (top, cyan and blue respectively) and midcortical and 2 mm subcortical surfaces were generated using a Laplacian potential (top, red and green respectively). These surfaces were registered to diffusion and DESPOT space using the FA image (middle left) and IR-SPGR (middle right) respectively. Measurements from diffusion and DESPOT scans were sampled along these surfaces (bottom). Examples of mean values in patients on the two surfaces are shown for diffusion (FA, MD, ICVF) and DESPOT (MWF) scans.