Table 9.

Absolute and relative organ weights of male and female rats administered GT by gavage for 13 weeks

Parameter measured (mean ± SD)	Dose group (mg TOS/kg body weight)
	Males (n = 10)				Females (n = 10)
	0 (control)a	161	643	2,570	0 (control)a	161	643	2,570
Absolute organ weight
Brain (g)	2.24 ± 0.08	2.21 ± 0.07	2.23 ± 0.09	2.18 ± 0.07	1.98 ± 0.10	2.00 ± 0.08	2.00 ± 0.10	2.03 ± 0.10
Heart (g)	1.46 ± 0.20	1.46 ± 0.12	1.41 ± 0.11	1.55 ± 0.13	0.86 ± 0.08	0.90 ± 0.12	0.89 ± 0.09	0.87 ± 0.05
Liver (g)	12.16 ± 1.84	12.41 ± 1.42	12.64 ± 1.32	13.22 ± 1.49	6.38 ± 0.70	6.55 ± 1.22	6.79 ± 0.52	6.62 ± 0.93
Kidneys (g)	3.10 ± 0.33	3.11 ± 0.22	2.96 ± 0.32	3.29 ± 0.29	1.72 ± 0.14	1.73 ± 0.22	1.86 ± 0.12	1.82 ± 0.15
Spleen (g)	0.69 ± 0.11	0.71 ± 0.08	0.71 ± 0.08	0.78 ± 0.09	0.46 ± 0.05	0.47 ± 0.07	0.48 ± 0.07	0.47 ± 0.09
Adrenal glands (mg)	54 ± 9	55 ± 6	56 ± 14	58 ± 10	59 ± 8	63 ± 9	61 ± 10	57 ± 10
Testes (g)	3.32 ± 0.26	3.31 ± 0.35	3.39 ± 0.22	3.25 ± 0.19	–	–	–	–
Ovaries (mg)	–	–	–	–	70 ± 18	76 ± 12	83 ± 13	77 ± 11
Thymus (mg)	297 ± 46	338 ± 83	285 ± 47	334 ± 74	274 ± 73	249 ± 54	247 ± 38	269 ± 74
Uterus (mg)	–	–	–	–	754 ± 429N	635 ± 179	547 ± 87	705 ± 221
Epididymides (mg)	1,204 ± 84	1,201 ± 70	1,247 ± 111	1,194 ± 147	–	–	–	–
Relative organ weight (%)
Brain	0.461 ± 0.055	0.444 ± 0.036	0.450 ± 0.046	0.430 ± 0.033	0.741 ± 0.061	0.755 ± 0.088	0.727 ± 0.061	0.751 ± 0.090
Heart	0.296 ± 0.020	0.292 ± 0.013	0.284 ± 0.033	0.305 ± 0.023	0.323 ± 0.031	0.334 ± 0.020	0.322 ± 0.035	0.321 ± 0.033
Liver	2.468 ± 0.165	2.470 ± 0.135	2.533 ± 0.126	2.590 ± 0.226	2.379 ± 0.159	2.424 ± 0.126	2.464 ± 0.142	2.415 ± 0.199
Kidneys	0.633 ± 0.057	0.620 ± 0.027	0.594 ± 0.042	0.645 ± 0.032	0.644 ± 0.061	0.646 ± 0.036	0.678 ± 0.076	0.671 ± 0.069
Spleen	0.141 ± 0.018	0.142 ± 0.018	0.142 ± 0.018	0.153 ± 0.013	0.171 ± 0.024	0.177 ± 0.023	0.176 ± 0.022	0.173 ± 0.030
Adrenal glands	0.011 ± 0.002	0.011 ± 0.002	0.011 ± 0.003	0.011 ± 0.002	0.022 ± 0.003	0.024 ± 0.004	0.022 ± 0.003	0.021 ± 0.003
Testes	0.685 ± 0.111	0.663 ± 0.086	0.691 ± 0.123	0.639 ± 0.049	–	–	–	–
Ovaries	–	–	–	–	0.026 ± 0.007N	0.028 ± 0.003	0.030 ± 0.003	0.028 ± 0.004
Thymus	0.061 ± 0.008	0.067 ± 0.015	0.058 ± 0.011	0.065 ± 0.012	0.103 ± 0.029	0.095 ± 0.027	0.090 ± 0.020	0.098 ± 0.022
Uterus	–	–	–	–	0.283 ± 0.165N	0.241 ± 0.082	0.200 ± 0.041	0.260 ± 0.090
Epididymides	0.249 ± 0.039	0.241 ± 0.020	0.252 ± 0.035	0.235 ± 0.031	–	–	–	–

Abbreviations: GT, glutaminase from nongenetically modified A. niger strain GT147; N, nonparametric analysis; SD, standard deviation; TOS, total organic solids.

^aControl animals were administered water.