Tulandi 1989.
Methods | Truly randomised (computer‐generated random numbers) Time of randomisation: 1 year after initial surgery 74 women randomised Some women lost to follow up after randomisation ‐ taken into account in life‐table analysis Duration of follow up: 36 months | |
Participants | Women who had failed to conceive within 12 months of undergoing tubal microsurgery with instillation of 32% dextran (38 had salpingo‐ovariolysis and 36 bilateral terminal salpingostomy). Mean age 30 years, duration of infertility at least 1 year prior to initial surgery. Other than tubal factor, further infertility work‐up (semen analysis, endometrial biopsy, luteal phase progesterone) was normal. HSG performed preoperatively in all women. Women with endometriosis were excluded from entry into the study. The trial was carried out over 2 years from 1986‐1988 at the Fertility Centre, McGill University, Montreal, Canada. | |
Interventions | Laparoscopic tubal patency testing +/‐ laparoscopic adhesiolysis where indicated versus no laparoscopy 12 months after initial tubal microsurgery | |
Outcomes | Outcomes of relevance to this review: Cumulative probability of pregnancy, live birth and ectopic pregnancy at 12, 24 and 36 months ‐ rates per woman could be calculated Method of diagnosis of pregnancy: urine pregnancy test and ultrasound Ectopic pregnancy rate Tubal patency rate (of at least 1 fallopian tube, per woman) | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Low risk | Computer generated random number tables. |
Allocation concealment? | Low risk | Opaque envelopes. |
Blinding? All outcomes | Unclear risk | Not stated within text. |
Incomplete outcome data addressed? All outcomes | Low risk | |
Free of selective reporting? | Low risk | |
Free of other bias? | Low risk |
HSG hysterosalpingogram
PCT postcoital test