Summary of findings 2. Multiple pregnancy.
| Multiple pregnancy | ||||||
| Patient or population: Women undergoing assisted reproduction Intervention: Assisted hatching compared with no assisted hatching | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Assisted hatching | |||||
| Multiple pregnancy rate per woman randomised | 102 per 1000 | 136 per 1000 (112 to 162) | OR 1.38 (1.11 to 1.7) | 3447 (14 studies) | ⊕⊕⊝⊝ low1,2 | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 There was methodological limitations or missing information in most trials 2 I square statistic was 57%