Antinori 1999.
Methods | Randomisation stated, but method unclear or incorrect Allocation concealment unclear Unclear if single/multicentre Participants not blinded or unclear Assessor not blinded or unclear Unclear if power calculation performed ITT analysis unclear Published as abstract | |
Participants | 341 Women from Italy undergoing IVF. Subgrouped by previous IVF experience: a) without previous IVF experience (n=199) or b) with more than 6 previous IVF failures (n=142) Mean age: control group 27.0; AH group 27.5 years | |
Interventions | AH (laser; complete zona breach; unclear how long from egg retrieval to AH; unclear how long from AH to transfer) ‐ 169 women randomised, 221 embryos transferred (estimated) versus Control ‐ no AH ‐172 women randomised, 247 embryos transferred (estimated) |
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Outcomes | Clinical pregnancy, miscarriage, multiple pregnancy | |
Notes | No reply No of embryos transferred: AH 2.3, Control 2.4 |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation stated, but method unclear or incorrect. Day not stated |
Allocation concealment (selection bias) | Unclear risk | Unclear |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Unclear. Participants not blinded or unclear. Assessor not blinded or unclear |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | ITT analysis unclear and no evidence of any losses |
Selective reporting (reporting bias) | Unclear risk | This is a conference abstract. There is no evidence of a full paper, live birth was not reported |