Ciray 2005.
Methods | Single centre Power calculation not reported ITT analysis not stated Published as full paper | |
Participants | 114 women from Turkey undergoing ART for ASRM grade 3 to 4 endometrosis only (poor prognosis) Age < 40 years: AH group 33.1 (4.2); Control group 34.0 (3.7) Basal FSH: AH group 7.4 (3.5); Control group 9.0 (5.1) | |
Interventions | Laser hatching (thinning to a quarter), 76 women randomised, 146 embryos transferred (16 cancelled) versus No hatching, only fresh embryo transfer cycles, 38 women randomised, 72 embryos transferred (8 cancelled) |
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Outcomes | Clinical pregnancy rate, implantation rate | |
Notes | No. of embryos: AH 2.4; Control 2.4 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomised, method stated 2:1 date, with the aid of computer programme |
Allocation concealment (selection bias) | Unclear risk | Unclear no details |
Blinding (performance bias and detection bias) All outcomes | High risk | No evidence of blinding of participants or assessors |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | All women appear to have been analysed |
Selective reporting (reporting bias) | Unclear risk | All outcomes reported but original protocol not viewed, live birth was not reported |