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. 2012 Dec 12;2012(12):CD001894. doi: 10.1002/14651858.CD001894.pub5

Ciray 2005.

Methods Single centre 
 Power calculation not reported 
 ITT analysis not stated 
 Published as full paper
Participants 114 women from Turkey undergoing ART for ASRM grade 3 to 4 endometrosis only (poor prognosis) 
 Age < 40 years: AH group 33.1 (4.2); Control group 34.0 (3.7) 
 Basal FSH: AH group 7.4 (3.5); Control group 9.0 (5.1)
Interventions Laser hatching (thinning to a quarter), 76 women randomised, 146 embryos transferred (16 cancelled)
versus
No hatching, only fresh embryo transfer cycles, 38 women randomised, 72 embryos transferred (8 cancelled)
Outcomes Clinical pregnancy rate, implantation rate
Notes No. of embryos: AH 2.4; Control 2.4
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomised, method stated 2:1 date, with the aid of computer programme
Allocation concealment (selection bias) Unclear risk Unclear no details
Blinding (performance bias and detection bias) 
 All outcomes High risk No evidence of blinding of participants or assessors
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk All women appear to have been analysed
Selective reporting (reporting bias) Unclear risk All outcomes reported but original protocol not viewed, live birth was not reported