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. 2012 Dec 12;2012(12):CD001894. doi: 10.1002/14651858.CD001894.pub5

Fang 2010.

Methods Single centre randomised controlled trial
Participants 125 women in China who had their first IVF/ICSI cycles between 2006 and 2008 with fresh IVF‐ET failures or without fresh embryo transfers
Mean age: 32.3 in AH group, 32.1 in control group
Setting: Fertility centre, China (2006 to 2008)
Interventions Mechanical assisted hatching: expanding/stretching the zona pellucida via injected hydrostatic pressure
AH: 61 women, 178 embryos
Control: 64 women, 190 embryos
Outcomes Clinical pregnancy and intrauterine implantation rates
Notes Unclear if power calculation performed 
 ITT analysis unclear 
 Published as full paper
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No details
Allocation concealment (selection bias) Unclear risk No details
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Embryologists blinded to the group assignment, unclear if participants were too
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Unclear
Selective reporting (reporting bias) High risk Original protocol not viewed. Live birth not reported