Fang 2010.
| Methods | Single centre randomised controlled trial | |
| Participants | 125 women in China who had their first IVF/ICSI cycles between 2006 and 2008 with fresh IVF‐ET failures or without fresh embryo transfers Mean age: 32.3 in AH group, 32.1 in control group Setting: Fertility centre, China (2006 to 2008) |
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| Interventions | Mechanical assisted hatching: expanding/stretching the zona pellucida via injected hydrostatic pressure AH: 61 women, 178 embryos Control: 64 women, 190 embryos |
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| Outcomes | Clinical pregnancy and intrauterine implantation rates | |
| Notes | Unclear if power calculation performed ITT analysis unclear Published as full paper | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | No details |
| Allocation concealment (selection bias) | Unclear risk | No details |
| Blinding (performance bias and detection bias) All outcomes | Unclear risk | Embryologists blinded to the group assignment, unclear if participants were too |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Unclear |
| Selective reporting (reporting bias) | High risk | Original protocol not viewed. Live birth not reported |