Lanzendorf 1998.
Methods | Single centre, randomised trial | |
Participants | 94 women from North America aged at least 36 years (mean basal FSH control 7.6 IU/L (SD 2.0); AH 7.9 IU/L (SD 2.5)), undergoing IVF (some with ICSI), half had been previously treated with IVF Mean age: control group 38.5 (0.26); AH group 38.3 (0.31) | |
Interventions | AH by acid tyrodes (chemical; complete zona breach; 55 hours egg retrieval to AH; ? hours AH to transfer) versus no AH AH: 42 women randomised, 180 embryos transferred Control: 52 women randomised, 212 embryos transferred | |
Outcomes | Implantation, clinical pregnancy, multiple pregnancy, live births | |
Notes | Attempted to contact author about this study. A reply including much useful additional information was received No. of embryos stated: AH 4.4; Control 4.4 Unclear if power calculation performed ITT analysis performed |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomised, method stated |
Allocation concealment (selection bias) | Low risk | Allocation concealment using sealed envelopes on day of aspiration |
Blinding (performance bias and detection bias) All outcomes | Low risk | Participants blinded Assessor blinded |
Incomplete outcome data (attrition bias) All outcomes | Low risk | ITT analysis performed |
Selective reporting (reporting bias) | Unclear risk | No evidence of selective reporting, although original protocol not viewed. Authors did report on live birth |