Nagy 1999.

Methods	Single centre, randomised trial
Participants	38 women from Italy with cryopreserved embryos undergoing IVF and ICSI Mean age: control group 31.4 (3.7); AH group 32.0 (4.0)
Interventions	AH (laser; complete zona breach; ? hours egg retrieval to AH; ? hours AH to transfer) with concomitant removal of damaged blastomeres versus no AH and no damaged blastomere removal AH: 20 women randomised, 65 embryos transferred Control: 18 women randomised, 52 embryos transferred
Outcomes	Clinical pregnancy
Notes	Attempted to contact author about this study. Reply received No. of embryos: AH: 2.9, control: 3.2 Unclear if power calculation performed ITT analysis unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation stated, but method unclear or incorrect
Allocation concealment (selection bias)	Unclear risk	Unclear, no details
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Participants not blinded or unclear Assessor not blinded or unclear
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	ITT analysis unclear
Selective reporting (reporting bias)	High risk	Published as a conference abstract only. No evidence of a full paper publication. The authors did not report on live birth