Nagy 1999.
Methods | Single centre, randomised trial | |
Participants | 38 women from Italy with cryopreserved embryos undergoing IVF and ICSI Mean age: control group 31.4 (3.7); AH group 32.0 (4.0) | |
Interventions | AH (laser; complete zona breach; ? hours egg retrieval to AH; ? hours AH to transfer) with concomitant removal of damaged blastomeres versus no AH and no damaged blastomere removal AH: 20 women randomised, 65 embryos transferred Control: 18 women randomised, 52 embryos transferred | |
Outcomes | Clinical pregnancy | |
Notes | Attempted to contact author about this study. Reply received No. of embryos: AH: 2.9, control: 3.2 Unclear if power calculation performed ITT analysis unclear |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation stated, but method unclear or incorrect |
Allocation concealment (selection bias) | Unclear risk | Unclear, no details |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Participants not blinded or unclear Assessor not blinded or unclear |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | ITT analysis unclear |
Selective reporting (reporting bias) | High risk | Published as a conference abstract only. No evidence of a full paper publication. The authors did not report on live birth |