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. 2012 Dec 12;2012(12):CD001894. doi: 10.1002/14651858.CD001894.pub5

Ng 2005.

Methods Randomised trial
Participants 160 women from Hong Kong with frozen embryo transfer 
 Mean age 34.0 years
Interventions Laser assisted thinning 1/4 with frozen embryos compared to frozen embryos
AH: 80 women
Control: 80 women
Outcomes Clinical pregnancy, miscarriage and multiple pregnancy rates
Notes No author contact as all details clearly stated in article 
 No. of embryos stated: AH, transferred 2 in 52.5% and 3 in 41.3%; Control, transferred 2 in 36.2% and 3 in 61.3%
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomisation pm day of frozen embryo transfer, computergenerated randomisation in sealed envelopes on day of ET
Allocation concealment (selection bias) Unclear risk 'sealed envelopes' used but unclear if these were opaque and how they were numbered
Blinding (performance bias and detection bias) 
 All outcomes Low risk double blinding until completion of the study
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No evidence of attrition bias
Selective reporting (reporting bias) Unclear risk Original protocol not viewed. The authors did not report on live birth