Ryan 1997.

Methods	Single centre, randomised trial
Participants	200 women from Sydney Australia undergoing ART cycles
Interventions	AH: tyrodes complete breach ‐ hole chemical means on both fresh and frozen‐thawed embryos: 100 women Control: 100 women
Outcomes	Clinical pregnancy
Notes	Additional information was received from the 1st author regarding the definition of pregnancy. No further publication is planned Mean ET 2.17
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table
Allocation concealment (selection bias)	Unclear risk	Unclear if allocation concealed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear if blinding took place
Incomplete outcome data (attrition bias) All outcomes	Low risk	All women randomised appear to have been analysed
Selective reporting (reporting bias)	High risk	Original protocol not viewed. Authors did not report on live birth