Figure 6.
MiR-3150b-3p inhibited Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling through downregulating Golgi phosphoprotein 3 (GOLPH3) expression. GOLPH3 protein levels, total and phosphorylated proteins of JAK2 and STAT3, and the protein levels of survivin, c-Myc, matrix metalloproteinase (MMP)-2/9 in HCT116 cells co-transfected with miR-3150b-3p mimic or mimic NC along with pcDNA3.1-GOLPH3 or blank vector. Significant differences were indicated as **p<0.01.