Table 2.
Effect size of clinical and genetic factors influencing measured lowest mean blood pressure in preterm infants on the first day of life
| Exposure | Number of infants exposed | Lowest mean blood pressure on day 1 in exposed infants (mm Hg) mean±SD | Effect size in linear regression analysis (mm Hg) (95% CI) |
P value* |
| All infants | 5380 | 27.7±6.3 | n.a. | |
| Higher gestational age (per week) | 5380 | n.a. | +1.18 (+1.10 to +1.25) | <0.001 |
| Antenatal treatment with steroids | 4939 | 27.8±6.3 | +1.01 (+0.47 to +1.56) | <0.001 |
| Genetic score blood pressure (per cumulated beta-coefficient) | 5380 | n.a. | +0.06 (+0.01 to +0.12) | 0.032 |
| APGAR score <7 at 5 min | 959 | 25.3±6.2 | −0.01 (−0.41 to +0.40) | 0.967 |
| Multiple birth | 1504 | 27.6±6.5 | −0.64 (−0.96 to −0.31) | <0.001 |
| Birth by emergency caesarean section | 571 | 26.0±5.9 | −0.87 (−1.35 to −0.39) | <0.001 |
| Mechanical ventilation on the first day of life | 2253 | 25.0±5.8 | −2.24 (−2.58 to −1.91) | <0.001 |
*Linear regression analysis was limited to 5380 infants due to missing data for APGAR score (n=178) and emergency caesarean section (n=24).
n.a., not available.