Table 3.
Logistic regression of 28-day mortality
Exposure | Number of infants exposed | Mortality in exposed infants (%) | OR (95% CI) for 28-day mortality in multivariate logistic regression analysis | P value* |
All infants | 5380 | 2.4 | n.a. | n.a. |
Higher gestational age (per week) | 5380 | n.a. | 0.81 (0.73 to 0.90) | <0.001 |
Antenatal treatment with steroids | 4939 | 2.2 | 0.66 (0.38 to 1.17) | 0.15 |
Measured lowest mean blood pressure on day 1 (per additional mm Hg) | 5380 | n.a. | 0.96 (0.92 to 0.998) | 0.038 |
Genetic score blood pressure >P75 | 1340 | 1.6 | Ref. | Ref. |
Genetic score blood pressure P25–P75 | 2689 | 2.4 | 1.55 (0.90 to 2.68) | 0.11 |
Genetic score blood pressure <P25 | 1351 | 3.2 | 2.10 (1.18 to 3.74) | 0.012 |
APGAR score <7 at 5 min | 959 | 5.3 | 1.36 (0.89 to 2.06) | 0.15 |
Multiple birth | 1504 | 2.9 | 1.55 (1.02 to 2.35) | 0.039 |
Birth by emergency caesarean section | 571 | 4.0 | 1.34 (0.79 to 2.29) | 0.28 |
Mechanical ventilation on the first day of life | 2253 | 4.6 | 1.64 (0.97 to 2.76) | 0.065 |
Dopamine | 512 | 8.4 | 0.98 (0.62 to 1.54) | 0.92 |
Dobutamine | 595 | 9.9 | 1.83 (1.18 to 2.83) | 0.007 |
Norepinephrine | 299 | 12.7 | 1.76 (1.08 to 2.88) | 0.023 |
Epinephrine | 297 | 23.2 | 9.90 (6.47 to 15.1) | <0.001 |
n.a., not available.