Table 4.
Mortality and complications of premature birth stratified to genetic score blood pressure (gsBP)
| gsBP | OR (95% CI) Low vs high |
P value* Low vs high |
|||
| Low (<25th percentile), n=1395 | Intermediate (25th–75th percentile), n=2790 | High (>75th percentile), n=1395 | |||
| Mortality | 63/1395 (4.5%) | 106/2790 (3.8%) | 40/1395 (2.9%) | 1.60 (1.07–2.40) | 0.027 |
| Mortality within the first 28 days | 44/1395 (3.2%) | 66/2790 (2.4%) | 21/1395 (1.5%) | 2.13 (1.26–3.60) | 0.005 |
| Intraventricular haemorrhage (IVH) | 280/1393 (20.1%) | 1497/2788 (17.8%) | 237/1395 (17.0%) | 1.23 (1.02–1.49) | 0.036 |
| IVH grade III or IV | 97/1392 (7.0%) | 174/2787 (6.2%) | 73/1393 (5.2%) | 1.35 (0.99–1.85) | 0.058 |
| Periventricular leukomalacia | 49/1392 (3.5%) | 88/2786 (3.2%) | 50/1392 (3.6%) | 0.98 (0.66–1.46) | 1.000 |
| Bronchopulmonary dysplasia | 270/1394 (19.4%) | 511/2784 (18.4%) | 261/1394 (18.7%) | 1.04 (0.86–1.26) | 0.700 |
| Sepsis | 177/1393 (12.7%) | 338/2785 (12.1%) | 171/1393 (12.3%) | 1.04 (0.83–1.30) | 0.775 |
| Surgery for necrotising enterocolitis | 30/1395 (2.2%) | 71/2790 (2.5%) | 35/1395 (2.5%) | 0.85 (0.52–1.40) | 0.616 |
| Surgery for persistent ductus arteriosus | 73/1395 (5.2%) | 117/2790 (4.2%) | 47/1395 (3.4%) | 1.58 (1.09–2.30) | 0.019 |
| Surgery for retinopathy of prematurity or vascular endothelial growth factor antibodies | 51/1395 (3.7%) | 99/2790 (3.5%) | 43/1395 (3.1%) | 0.70 (0.43–1.14) | 0.463 |
*Two-sided p value comparing groups with low vs high gsBP. Fisher’s exact test was used to compare variables.