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. 2019 Jul 24;7(1):52–61. doi: 10.1016/j.gendis.2019.07.004

Figure 2.

Figure 2

Schematic representation of SCID genes and their associated domains. (A)RAG1 gene showing core region domains as nonamer binding domain (NBD), a central domain and the C′ terminal domain. The non-core region have zinc dimerization domain (ZDD) having zinc finger A (ZFA), central non-core domain (CND). The three active site residues are shown by D600, D708 and E649. (B)RAG2 gene showing the 6-bladed beta-propeller structure in the N terminal core region. The non-core region shows acidic hinge region and plant homeodomain (PHD). (C)DCLRE1C gene (Artemis) showing three distinct regions belonging to Metallo-β−lactamase superfamily namely β-lactamase domain, β- CASP domain and C′ terminal domain. (D)PRKDC gene showing 5′ DNA interacting site, leucine-rich repeats, phosphorylation cluster. sites (PQR, ABCDE), helix-turn-helix repeats while FAT, FATC, PI3K kinase domains and caspase 3 cleavage site are present at C-terminal region. (E)IL2RG gene showing Interleukin-6 receptor alpha binding domain (IL6Ra-bind), fibronectin III binding domain (FN3), the WSXWS motif, transmembrane domain (TM), and Box 1 domain.