Table 1.
Broad classification of severe combined immunodeficiency (SCID) based on flow cytometry.
| T-B + SCID | Genes | T-B- SCID | Genes |
|---|---|---|---|
| IL2R common gamma chain | IL2RG | Recombinase-activating genes 1 and 2 | RAG1/RAG2 |
| Janu kinase 3 | JAK3 | DNA cross-link repair enzyme 1c (Artemis) | DCLRE1C |
| IL7-RA Chain | IL7RA | DNA dependent protein kinase | PRKDC |
| IL2 RA CD25 deficiency | IL2R | Adenylate kinase (reticular dysgenesis) | AK2 |
| CD45(Protein tyrophospahtase receptor type C) | PTPRC | Adenosine deaminase | ADA |
| CD3-delta | CD3D | DNA Ligase 4 | LIG4 |
| CD3-Zeta | CD3ζ | Non-homologous end joining protein 1(Cernunnos) | NHEJ1 |
| CD3-Epsilon | CD3ε | ||
| Coronin 1A | CORO1A |