Figure 1.

Gene structure of TNFRSF6 (TNF-receptor superfamily 6) gene located at chromosome position10q23.31. The numbers 1 to 9 denote the number of exons. Exon 1–6 encode extracellular and trans membrane domain while intracellular domain is encoded from exon 7–9. The death domain is encoded within exon 9. Star denotes somatic mutations in the various domains of the gene, most of the mutations being frameshift. Intracellular domain (majorly death domain) is the hotspot for most mutations. a.a. denotes position of amino acids.