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. 2020 Mar 3;11:139. doi: 10.3389/fphys.2020.00139

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Copyright © 2020 Li, Long, Chen, Zhang, Qin, Zhong, Liu and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Verification of sepsis-induced AKI-specific biomarkers in sepsis human patients. (A) The concentration of nine proteins was validated by ELISA in urine from sepsis-induced AKI patients and non-sepsis-induced AKI patients. ^∗P < 0.05; two-tailed unpaired Student’s t-test. (B) Validation of 4 differentially expressed proteins by testing their performance in differentiating injury specificity by AUC for PARK7, PGLYRP2, AXL, and CDH16. (C) Pearson correlation analysis was performed between expression of PARK7 and CDH16 and Scr. Both PARK7 and CDH16 were correlated to Scr. P < 0.01; (D) The protein expression of PARK7 and CDH16 in urine from ten patients were detected by Elisa kit at 0, 6, 12, and 24 h after diagnosis with sepsis. **P < 0.01; ***P < 0.001;Compared with 0 h.