Table 2.
Toxicokinetic Parameters a for Vinpocetine and Apovincaminic Acid in Dam Plasma Following a Daily Gavage Dose of Vinpocetine in HSD Rats from GD6 to GD18
| Parameter | Dose | |
|---|---|---|
| 5mg/kg | 20mg/kg | |
| Vinpocetineb | ||
| Cmax_Observed (ng/mL)c | 497 | 1420 |
| Cmax_Predicted (ng/mL) | 342 (36) | 948 (133) |
| Tmax Observed (h) | 0.750 | 0.750 |
| Tmax Predicted (h) | 1.11 (0.28) | 1.37 (0.40) |
| K01(h−1) | 2.44 (0.94) | 1.94 (0.88) |
| K01 Half-Life (h) | 0.284 (0.110) | 0.358 (0.162) |
| K10 (h−1) | 0.201 (0.015) | 0.173 (0.019) |
| K10 Half-Life (h) | 3.45 (0.25) | 4.02 (0.45) |
| AUC (0-T) (ng/mL.h) | 1830 | 7020 |
| AUC∞ (ng/mL.h) | 2120 (220) | 6960 (940) |
| Cl1_F (mL/h/kg) | 2350 (240) | 2870 (390) |
| V1_F (mL/kg) | 11700 (1700) | 16700 (3330) |
| Apovincaminic Acidd | ||
| Cmax_Observed (ng/mL) | 1070 | 2560 |
| Tmax Observed (h) | 1.50 | 1.00 |
| λz (h−1) | 0.170 | 0.157 |
| Half-life (h) | 4.07 | 4.41 |
| AUC (0-T) (ng/mL.h) | 6060 | 23500 |
| AUC∞ (ng/mL.h) | 6170 | 24200 |
| Cl1_F (mL/h/kg) | 811 | 826 |
| V1_F (mL/kg) | 4760 | 5250 |
a
Values given are mean (standard error, SE).
b
Based on one-compartmental model with first order input, first order output, and 1/Yhat2 weighting.
c
Observed values have no SE to report.
d
Based on non-compartmental analysis (NCA).