Table 3.
Toxicokinetic Parameters a for Vinpocetine and Apovincaminic Acid in Fetuses Following a Daily Gavage Dose of Vinpocetine in HSD Rats from GD6 to GD18.
| Parameter | Dose | |
|---|---|---|
| 5 mg/kg | 20 mg/kg | |
| Vinpocetine | ||
| Cmax_Observed (ng/g) | 321 | 768 |
| Tmax Observed (h) | 1.00 | 0.750 |
| λz (h−1) | 0.222 | 0.214 |
| Half-life (h) | 3.12 | 3.23 |
| AUC (0-T) (ng/g.h) | 1150 | 4260 |
| AUC∞ (ng/g.h) | 1160 | 4300 |
| Cl1_F (g/h/kg) | 4330 | 4650 |
| V1_F (g/kg) | 19500 | 21700 |
| Apovincaminic Acid | ||
| Cmax_Observed (ng/g) | 25.0 | 83.7 |
| Tmax Observed (h) | 8.00 | 4.00 |
| λz (h−1) | 0.136 | 0.108 |
| Half-life (h) | 5.09 | 6.42 |
| AUC (0-T) (ng/g.h) | 334 | 1160 |
| AUC∞ (ng/g.h) | 353 | 1290 |
| Cl1_F (g/h/kg) | 14100 | 15600 |
| V1_F (g/kg) | 104000 | 144000 |
a
Based on non-compartmental analysis.