Table 4.
Toxicokinetic Parametersa for Vinpocetine and Apovincaminic Acid in Amniotic Fluid Following a Daily Gavage Dose of Vinpocetine in HSD Rats from GD6 to GD18.
| Parameter | Dose | |
|---|---|---|
| 5mg/kg | 20mg/kg | |
| Vinpocetine | ||
| Cmax_Observed (ng/mL) | 21.4 | 45.0 |
| Tmax Observed (h) | 1.00 | 0.750 |
| λz (h−1) | 0.178 | 0.184 |
| Half-life (h) | 3.90 | 3.77 |
| AUC (0-T) (ng/g·h) | 97.3 | 310 |
| AUC∞ (ng/mL.h) | 98.7 | 316 |
| Cl1_F (mL/h/kg) | 50600 | 63300 |
| V1_F (mL/kg) | 285000 | 345000 |
| Apovincaminic Acid | ||
| Cmax_Observed (ng/mL) | 4.93 | 23.0 |
| Tmax Observed (h) | 24.0 | 24.0 |
| λz (h−1) | NA | NA |
| Half-life (h) | NA | NA |
| AUC (0-T) (ng/mL/h) | 99.1 | 440 |
| AUC∞ (ng/mL.h) | NA | NA |
| Cl1_F (mL/h/kg) | NA | NA |
| V1_F (mL/kg) | NA | NA |
a
Based on non-compartmental analysis.