Table 5.
Comparison of Dose-Normalized AUC and Cmax of Vinpocetine and Apovincaminic Acid in Rodents
| Rat Strain | Dose | Vinpocetine | Apovincaminic Acid | Reference | ||
|---|---|---|---|---|---|---|
| (mg/kg) | Cmax/Dose (ng/mL)/(mg/kg) | AUC/Dose (ng/ml).h/(mg/kg) | Cmax/Dose (ng/mL)/(mg/kg) | AUC/Dose (ng/ml).h/(mg/kg) | ||
| Hsd:Sprague Dawley® SD® Rats | 5 | 68.4 | 424 | 214 | 1234 | Current study |
| Hsd:Sprague Dawley® SD® Rats | 20 | 47.4 | 348 | 128 | 1210 | Current study |
| Wistar | 2.5 | NA | 261.6 | NA | 3089 | Vereczkey et al., 1979b |
| Sparague Dawley | 1 | 23.8 | 57.4 | 86.6 | 472 | Xie et al., 2010 |
| Wistar | 2 | 67.6 | 262 | NA | NA |
Sozanski et al., 2011 |