REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
E. coli BL21 Star DE3	Invitrogen	Cat#C601003
E. coli DH5α	Invitrogen	Cat#18265017
Biological Samples
HFE C282Y genomic DNA homozygous samples	Coriell	Cat#NA14620
HFE C282Y genomic DNA heterozygous samples	Coriell	Cat#NA14691
CFTR phe508del genomic DNA homozygous samples	Coriell	Cat#NA01531
CFTR phe508del genomic DNA heterozygous samples	Coriell	Cat#NA20929
BRCA2 6174delT genomic DNA homozygous samples	Coriell	Cat#NA14170
Control genomic DNA samples	Coriell	Cat#NA16660
America Zika RNA genomic sample	BEI	Cat#NR-50244
Asian Zika RNA genomic sample	BEI	Cat#NR-50244
Africa Zika RNA genomic sample	BEI	Cat#NR-50085
BRCA2 c.8904delC blood sample	This paper	N/A
BRCA2 c.8167G > C blood sample	This paper	N/A
Chemicals, Peptides, and Recombinant Proteins
Chlorophenol red-β-D-galactopyranoside	Sigma-Aldrich	Cat#59767
RNase inhibitor	Roche	Cat#3335399001
Phusion High-Fidelity PCR Master Mix with HF Buffer	New England Biolabs	Cat#M0531S
Critical Commercial Assays
AmpliScribe T7-Flash Transcription Kit	Lucigen	Cat#ASF3257
PURExpress In Vitro Protein Synthesis Kit	New England Biolabs	Cat#E6800L
RT-RPA kit	TwistDX	Cat#TALQBASRT01
Basic RPA kit	TwistDX	Cat#TABAS03KIT
RNA Clean and Concentrator Kit	Zymo Research	Cat#R1017
QIAamp DNA Blood mini kit	QIAGEN	Cat#51104
Oligonucleotides
DNA oligonucleotides	Integrated DNA Technologies	See Tables S1, S2, S3, S4, and S5 for DNA primers used and DNA template sequences
Chemically modified RNA	Integrated DNA Technologies	See Table S2 for sequences of chemically modified RNA
Recombinant DNA
GFPmut3b gene	Green et al., 2014	Available on Addgene plasmid p_SNIPR_sensor_GFP (#139463)
β-galactosidase gene	Pardee et al., 2016	Available on Addgene plasmid p_SNIPR_sensor_LacZ (#139464)
Software and Algorithms
SNIPR design software	This paper	https://github.com/Albert09111/SNIPR