Inhibition of subcutaneous tumor growth by docetaxel or FABP5 inhibitors. PC3 cells (1 × 106) were implanted subcutaneously into male BALB/c nude mice. From day 15 onwards, mice were treated with vehicle, SBFI-102 (20 mg/kg, daily), SBFI-103 (20 mg/kg, daily), or docetaxel (5 mg/kg or 10 mg/kg, weekly). A, Tumor growth over the time course of treatments. B-D, Tumor volumes at days 25, 30, and 35, respectively. *P < .05 versus vehicle treatment; **P < .01 versus vehicle treatment; ***P < .001 versus vehicle treatment; #P < .05 versus 10 mg/kg docetaxel treatment; ##P < .01 versus 10 mg/kg docetaxel treatment; (n = 5). FABP5, fatty acid-binding protein; SBFI, Stony Brook fatty acid-binding protein inhibitor [Color figure can be viewed at wileyonlinelibrary.com]