TABLE 1.
Synergy analysis for SBFI-102 or SBFI-103 and docetaxel combinations in PC3, DU-145, and 22Rv1 cell-lines
| Cell-line | SBFI-102, μM | SBFI-103, μM | Docetaxel, nM | Fa value | CI value | Relationship |
|---|---|---|---|---|---|---|
| PC3 | 7.5 | – | 0.03 | 0.786 | 0.897 | Synergistic |
| PC3 | 7.5 | – | 0.3 | 0.950 | 0.009 | Synergistic |
| PC3 | 7.5 | – | 3.0 | 0.992 | 0.160 | Synergistic |
| PC3 | – | 1.0 | 0.03 | 0.402 | 0.710 | Synergistic |
| PC3 | – | 1.0 | 0.3 | 0.432 | 0.889 | Synergistic |
| PC3 | – | 1.0 | 3.0 | 0.700 | 0.394 | Synergistic |
| DU-145 | 7.5 | – | 0.03 | 0.934 | 1.302 | – |
| DU-145 | 7.5 | – | 0.3 | 0.963 | 0.968 | Synergistic |
| DU-145 | 7.5 | – | 3.0 | 0.998 | 0.123 | Synergistic |
| DU-145 | – | 1.0 | 0.03 | 0.516 | 4.473 | – |
| DU-145 | – | 1.0 | 0.3 | 0.676 | 2.697 | – |
| DU-145 | – | 1.0 | 3.0 | 0.935 | 0.445 | Synergistic |
| 22Rv1 | 7.5 | – | 0.03 | 0.795 | 3.846 | – |
| 22Rv1 | 7.5 | – | 0.3 | 0.904 | 0.003 | Synergistic |
| 22Rv1 | 7.5 | – | 3.0 | 0.999 | 0.005 | Synergistic |
| 22Rv1 | – | 1.0 | 0.03 | 0.457 | 1.673 | – |
| 22Rv1 | – | 1.0 | 0.3 | 0.744 | 0.373 | Synergistic |
| 22Rv1 | – | 1.0 | 3.0 | 0.905 | 0.267 | Synergistic |
Abbreviations: Fa, fraction of cells affected; CI, combination-index; SBFI, Stony Brook fatty acid binding protein inhibitor.