Table 1.
Risk factors in South Asians compared with Caucasians
| Risk marker | Potential mechanism | Contribution SAs vs Caucasians |
|---|---|---|
| Diabetes/dysglycemia | Multiple | ↑ |
| Hypertension | Multiple | ↑ or ↔ |
| LDL-C | Direct | ↔ |
| HDL-C | Unknown | ↑ |
| Triglycerides | Unknown | ↑ |
| Abdominal obesity | Multiple | ↑ |
| hsCRP | Vascular Inflammation | ↑ |
| Adiponectin | Multiple | ↑ |
| Lp(a) | Atherothrombosis | ↑ |
| Genetics | Multiple | ? |
| Diet | Multiple | ↑ |
| Physical activity | Multiple | ↑ |
| Lipid particle size | Direct? | ↑ |
| PAI-1/fibrinogen | Thrombosis | ↑ |
| Fetal origins | Multiple | ↑ |
↑ indicates greater risk contributor in South Asians. ↔ indicates similar risk contributor in South Asians and whites.
HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein a; PAI-1, plasminogen activator inhibitor 1.