Table 3.
Test characteristics of very low hs-cTnT thresholds on presentation
| hs-cTnT threshold |
Eligible N (%) |
Outcome | TP | FP | FN | TN | Sensitivity (95% CI) | NPV (95% CI) | LR– (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| < 3 ng/L | 191 (16.4%) | 30-d MACE | 123 | 853 | 2 | 189 | 98.4 (94.3, 99.8) | 99.0 (96.3, 99.9) | 0.09 (0.02, 0.35) |
| Index AMI | 97 | 879 | 0 | 191 | 100 (96.3,100) | 100 (98.1, 100) | 0 (0, NA) | ||
| 30-d AMI | 98 | 878 | 0 | 191 | 100 (96.3,100) | 100 (98.1, 100) | 0 (0, NA) | ||
| 30-d revascularization | 69 | 907 | 2 | 189 | 97.2 (90.3-99.2) | 99.0 (96.3, 99.9) | 0.16 (0.04, 0.63) | ||
| 30-d cardiac death | 1 | 975 | 0 | 191 | 100 (20.7, 100) | 100 (98.1, 100) | 0 (0, NA) | ||
| <5 ng/L | 416 (35.6%) | 30 d MACE | 118 | 633 | 7 | 409 | 94.4 (88.8, 97.7) | 98.3 (96.6, 99.3) | 0.14 (0.07, 0.29) |
| Index AMI | 96 | 655 | 1 | 415 | 99.0 (94.5, 100) | 99.8 (98.7, 100) | 0 (0, NA) | ||
| 30 d AMI | 97 | 654 | 1 | 415 | 99.0 (94.5, 100) | 99.8 (98.7, 100) | 0 (0, NA) | ||
| 30 d revascularization | 64 | 687 | 7 | 409 | 90.1 (81.5, 95.3) | 98.3 (96.6, 99.3) | 0.26 (0.13, 0.52) | ||
| 30-d cardiac death | 1 | 750 | 0 | 416 | 100 (20.7, 100) | 100 (99.1, 100) | 0 (0, NA) | ||
| <6 ng/L | 507 (43.4%) | 30-d MACE | 115 | 545 | 10 | 497 | 92.0 (85.8, 96.1) | 98.0 (96.4, 99.1) | 0.17 (0.09, 0.31) |
| Index AMI | 95 | 565 | 2 | 505 | 97.9 (92.8, 99.8) | 99.6 (98.6, 100) | 0.04 (0.01, 0.17) | ||
| 30-d AMI | 96 | 564 | 2 | 505 | 98.0 (92.8, 99.8) | 99.6 (98.6, 100) | 0.04 (0.01, 0.17) | ||
| 30-d revascularization | 62 | 598 | 9 | 498 | 87.3 (77.6, 93.2%) | 98.2 (96.7, 99.1) | 0.28 (0.15, 0.52) | ||
| 30-d cardiac death | 1 | 659 | 0 | 507 | 100 (20.7, 100) | 100 (99.3, 100) | 0 (0, NA) |
FN, false-negative; FP, false-positive; hs-cTnT, high-sensitivity cardiac troponin T; LR–, negative likelihood ratio; MACE, major adverse cardiac events; NPV, negative predictive value; TN, true negative; TP, true-positive.