Table 4.
Test characteristics of very low hs-cTnT thresholds on presentation among patients with at least 3 hours since symptom onset
| hs-cTnT threshold |
Eligible N (%) |
Outcome | TP | FP | FN | TN | Sensitivity (95% CI) | NPV (95% CI) | LR– (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| < 3 ng/L | 126 (10.8%) | 30-d MACE | 125 | 916 | 0 | 126 | 100 (97.1-100) | 100 (97.1-100) | 0 (0-NA) |
| Index AMI | 97 | 944 | 0 | 126 | 100 (96.3-100) | 100 (97.1-100) | 0 (0-NA) | ||
| 30-d AMI | 98 | 943 | 0 | 126 | 100 (96.3-100) | 100 (97.1-100) | 0 (0-NA) | ||
| 30-d revascularization | 71 | 970 | 0 | 126 | 100 (95.0-100) | 100 (97.1-100) | 0 (0-NA) | ||
| 30-d cardiac death | 1 | 1040 | 0 | 126 | 100 (20.7-100) | 100 (97.1-100) | 0 (0-NA) | ||
| < 5 ng/L | 292 (25.0%) | 30-d MACE | 122 | 753 | 3 | 289 | 97.6 (93.2-100) | 99.0 (97.0-99.8) | 0.09 (0.03-0.27) |
| Index AMI | 97 | 778 | 0 | 292 | 100 (96.3-100) | 100 (98.7-100) | 0 (0-NA) | ||
| 30-d AMI | 98 | 777 | 0 | 292 | 100 (96.3-100) | 100 (98.7-100) | 0 (0-NA) | ||
| 30-d revascularization | 68 | 807 | 3 | 289 | 95.8 (88.3-98.6) | 99.0 (97.0-99.8) | 0.16 (0.05-0.49) | ||
| 30-d cardiac death | 1 | 874 | 0 | 292 | 100 (20.7-100) | 100 (98.7-100) | 0 (0-NA) | ||
| < 6 ng/L | 354 (30.3%) | 30-d MACE | 120 | 693 | 5 | 349 | 96.0 (90.9-98.7) | 98.6 (96.7-100) | 0.12 (0.05-0.28) |
| Index AMI | 97 | 716 | 0 | 354 | 100 (96.3-100) | 100 (99.0-100) | 0 (0-NA) | ||
| 30-d AMI | 98 | 715 | 0 | 354 | 100 (96.3-100) | 100 (99.0-100) | 0 (0-NA) | ||
| 30-d revascularization | 66 | 747 | 5 | 349 | 93.0 (84.6-97.0) | 98.6 (96.7-99.4) | 0.22 (0.10-0.52) | ||
| 30-d cardiac death | 1 | 813 | 0 | 354 | 100 (20.7-100) | 100 (99.0-100) | 0 (0-NA) |
AMI, acute myocardial infarction; CI, confidence interval; FN, false-negative; FP, false-positive; hs-cTnT, high-sensitivity cardiac troponin T; LR–, negative likelihood ratio; MACE, major adverse cardiac events; NA, not available; NPV, negative predictive value; TN, true negative; TP, true-positive.