Table 2.
Comparisons of inner intra-retinal layer thickness among controls and TAO patients with and without DON
| Layers | Regions | Control (C) | Non-DON (N) | DON (D) | P Value (C vs. N) | P Value (C vs. D) | P Value (N vs. D) |
|---|---|---|---|---|---|---|---|
| NFL (μm) | C | 6.9 ± 1.3 | 6.2 ± 1.7 | 6.9 ± 1.3 | 0.032 | 0.927 | 0.039 |
| TAZ | 19.9 ± 3.2 | 17.7 ± 2.1 | 17.4 ± 1.3 | < 0.001 | < 0.001 | 0.585 | |
| S | 21.4 ± 3.6 | 19.1 ± 3.3 | 18.0 ± 1.9 | 0.001 | < 0.001 | 0.126 | |
| T | 17.0 ± 2.7 | 15.5 ± 1.9 | 15.3 ± 1.9 | 0.005 | 0.001 | 0.681 | |
| I | 22.2 ± 3.6 | 19.1 ± 3.3 | 18.0 ± 1.9 | 0.001 | < 0.001 | 0.920 | |
| N | 19.3 ± 4.6 | 16.3 ± 2.2 | 16.5 ± 1.8 | < 0.001 | < 0.001 | 0.778 | |
| GCL + IPL (μm) | C | 14.6 ± 4.2 | 12.0 ± 4.1 | 12.0 ± 3.4 | 0.005 | 0.005 | 0.958 |
| TAZ | 75.4 ± 8.3 | 69.6 ± 10.2 | 67.1 ± 13.1 | 0.021 | 0.001 | 0.347 | |
| S | 79.5 ± 9.6 | 71.6 ± 11.0 | 69.2 ± 14.2 | 0.005 | < 0.001 | 0.387 | |
| T | 72.0 ± 13.4 | 65.1 ± 10.4 | 62.7 ± 12.8 | 0.018 | 0.001 | 0.406 | |
| I | 79.5 ± 9.6 | 71.6 ± 11.0 | 69.2 ± 14.2 | 0.005 | < 0.001 | 0.337 | |
| N | 74.9 ± 9.8 | 66.8 ± 10.6 | 64.9 ± 13.2 | 0.003 | < 0.001 | 0.479 | |
| GCC (μm) | C | 21.5 ± 5.0 | 18.2 ± 5.0 | 18.9 ± 3.7 | 0.002 | 0.015 | 0.499 |
| TAZ | 95.2 ± 10.3 | 87.3 ± 11.8 | 84.5 ± 13.4 | 0.005 | < 0.001 | 0.341 | |
| S | 100.8 ± 12.0 | 90.6 ± 13.1 | 87.2 ± 15.0 | 0.001 | < 0.001 | 0.270 | |
| T | 88.9 ± 14.5 | 80.6 ± 11.8 | 78.0 ± 11.9 | 0.006 | < 0.001 | 0.386 | |
| I | 101.6 ± 13.1 | 92.7 ± 12.5 | 90.1 ± 14.0 | 0.005 | < 0.001 | 0.400 | |
| N | 94.2 ± 13.2 | 83.1 ± 12.2 | 81.4 ± 13.2 | < 0.001 | < 0.001 | 0.581 | |
| INL + ORL (μm) | C | 202.2 ± 41.2 | 202.9 ± 9.6 | 206.3 ± 26.4 | 0.921 | 0.549 | 0.623 |
| TAZ | 219.3 ± 9.4 | 218.4 ± 7.1 | 221.4 ± 9.4 | 0.655 | 0.304 | 0.146 | |
| S | 219.6 ± 9.9 | 219.3 ± 7.5 | 221.6 ± 9.2 | 0.866 | 0.349 | 0.275 | |
| T | 221.8 ± 10.5 | 220.2 ± 8.2 | 224.0 ± 10.2 | 0.468 | 0.343 | 0.098 | |
| I | 216.5 ± 8.0 | 216.6 ± 7.2 | 219.9 ± 9.3 | 0.968 | 0.081 | 0.092 | |
| N | 218.6 ± 9.6 | 217.1 ± 6.8 | 220.5 ± 10.0 | 0.466 | 0.370 | 0.108 | |
| Total (μm) | C | 213.3 ± 51.3 | 214.7 ± 14.9 | 215.8 ± 36.9 | 0.870 | 0.771 | 0.901 |
| TAZ | 314.1 ± 17.5 | 305.4 ± 15.8 | 305.7 ± 12.8 | 0.019 | 0.021 | 0.937 | |
| S | 320.2 ± 19.5 | 309.7 ± 17.1 | 308.5 ± 14.8 | 0.011 | 0.004 | 0.772 | |
| T | 315.9 ± 21.8 | 302.9 ± 17.5 | 305.0 ± 14.9 | 0.003 | 0.012 | 0.635 | |
| I | 318.1 ± 19.1 | 309.2 ± 15.4 | 309.6 ± 12.9 | 0.020 | 0.025 | 0.915 | |
| N | 307.0 ± 21.5 | 297.1 ± 15.0 | 298.0 ± 11.5 | 0.012 | 0.021 | 0.806 |
TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; Control (C) = control subjects; Non-DON (N) = TAO patients without DON; DON (D) = TAO patients with DON; NFL = nerve fiber layer; GCL + IPL = ganglion cell layer and inner plexiform layer; GCC = ganglion cell complex; INL = inner nuclear layer; ORL = outer retinal layer; C = central region; TAZ = total annular zone; S = superior sector; T = temporal sector; I = inferior sector; N = nasal sector. Bold P-value represents < 0.01