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Algorithms for analyzing CRISPR-pooled screen data
| Algorithm | Original purpose | FDRs? | Guide inefficiencies? | Negative controls? | Single or multiple screens? |
|---|---|---|---|---|---|
| RSA | RNAi | No | No | No | Single |
| MAGeCK RRA | CRISPRko | Yes | No | Yes | Single |
| HiTSelect | CRISPRko & RNAi | Yes | Yes | Yes | Single |
| MAGeCK MLE | CRISPRko | Yes | Yes | Yes | Both |
| BAGEL | CRISPRko essentiality | Yes | No | Yes | Single |
| CERES | CRISPRko in cancer | Yes | Yes | No | Multiple |
| CRISPhieRmix | CRISPRi/a | Yes | Yes | Yes | Single |
