Table 2.

Area under the precision-recall curve (PR-AUC) for all algorithms applied to TKO datasets, using the combined non-human- and Chr10Rand-negative control guide RNAs

	HCT116_1	HCT116_2	DLD1	HeLa	RPE1	GBM	Average rank
MAGeCK RRA	0.449	0.505	0.508	0.424	0.450	0.461	2
MAGeCK MLE	0.404	0.476	0.372	0.395	0.402	0.346	3.7
CRISPhieRmix	0.459	0.435	0.032	0.391	0.502	0.535	2.7
RSA	0.346	0.415	0.439	0.340	0.389	0.368	4.5
t test	0.431	0.535	0.57	0.383	0.474	0.528	2.2

Each column corresponds to a specific cancer type. The average rank is calculated by taking the rank (1 to 5) for each screen and taking the arithmetic mean. The highest PR-AUC for each dataset is highlighted in bold