Table 2.

Summary of the results of the chronic in vivo studies in animals, with the LIFE, SELINE and regenerative electrodes

Interface	Longevity
LIFE	A life-time of 18-24 months is expected [179]; slight tissue damage in the early phase but normalizes after 6 months [180]
SELINE	Inflammatory response in the early phase, but stable after 6 months [181]
Regenerative electrodes	Inflammatory response to nerve transection, but good signal quality after 4 months [182]; another 12-month study observed regeneration and reliable signals in the first 6 months, but axonal damage and functional decline in the second 6 months [183]