Table 1.
Summary of demographic data
| EWAS | |||||||
| Group | Brain Bank | Sex | Age | PMI | |||
| CTRL | BBH: 9 | KCL: 28 | M: 19 | F: 18 | 73.0 ± 10.5 | 42.0 ± 19.2 | – |
| MSA | BBH: 17 | KCL: 24 | M: 17 | F: 24 | 66.0 ± 5.7 | 42.0 ± 26.3 | – |
| P | 0.150 | 0.496 | 7.12E-04 | 0.999 | – | ||
| RT-qPCR | |||||||
| Group | Brain Bank | Sex | Age | PMI | RIN | ||
| CTRL | BBH: 10 | NBB: 10 | M: 8 | F: 12 | 73.5 ± 12.0 | 28.2 ± 27.4 | 5.3 ± 0.6 |
| MSA | BBH: 16 | M: 5 | F: 11 | 64.4 ± 6.0 | 40.6 ± 20.3 | 5.1 ± 0.7 | |
| P | 7.58E-04 | 0.731 | 6.53E-03 | 0.128 | 0.373 | ||
| Flow cytometry | |||||||
| Group | Brain Bank | Sex | Age | ||||
| CTRL | BBH: 46 | M: 18 | F: 28 | 71.9 ± 9.4 | – | – | |
| MSA | BBH: 24 | M: 11 | F: 13 | 62.9 ± 7.9 | – | – | |
| P | – | 0.618 | 8.46E-05 | – | – | ||
Demographic summaries are shown for the cohorts for Illumina MethylationEPIC data (EWAS), RT-qPCR data, and flow cytometric data. Group differences were tested using Fisher’s exact test (sex, origin), or t-tests. Age in years at death is reported; CTRL normal, healthy control, MSA multiple system atropy, BBH Bispebjerg Brain Bank, KCL King’s College London Brain Bank, NBB Netherlands Brain Bank, M male, F female, PMI Post-mortem interval in hours, RIN RNA Integrity Number