Table 1.
Baseline clinical and laboratory characteristics of the study patients stratified by the primary endpoint
| Variable | No such events n = 588 |
Primary endpoint n = 188 |
P value |
|---|---|---|---|
| Demographics | |||
| Age (years) | 61 ± 10 | 62 ± 10 | 0.498 |
| Male sex, n (%) | 426 (72.4) | 134 (71.3) | 0.755 |
| BMI (kg/m2) | 26.2 ± 3.5 | 25.9 ± 3.1 | 0.298 |
| Medical measurements (on admission) | |||
| SBP (mm Hg) | 132 ± 18 | 131 ± 15 | 0.339 |
| DBP (mm Hg) | 76 ± 11 | 73 ± 10 | 0.001 |
| Risk factors | |||
| Cigarette smoking | |||
| Current smokers, n (%) | 238 (40.5) | 72 (38.3) | 0.596 |
| Former smokers, n (%) | 89 (15.1) | 35 (18.6) | 0.257 |
| Never smokers, n (%) | 261 (44.4) | 81 (43.1) | 0.754 |
| Alcohol intake | |||
| Daily drinkers, n (%) | 56 (9.5) | 18 (9.6) | 0.984 |
| Family history of CHD, n (%) | 172 (29.3) | 66 (35.1) | 0.130 |
| Hypertension, n (%) | 403 (68.5) | 129 (68.6) | 0.984 |
| Dyslipidaemia, n (%) | 483 (82.1) | 163 (86.7) | 0.145 |
| Previous MI, n (%) | 112 (19.0) | 54 (28.7) | 0.005 |
| Past PCI, n (%) | 120 (20.4) | 66 (35.1) | < 0.001 |
| Previous CVA, n (%) | 37 (6.3) | 11 (5.9) | 0.827 |
| PAD, n (%) | 62 (10.5) | 54 (28.7) | < 0.001 |
| CKD, n (%) | 40 (6.8) | 20 (10.6) | 0.087 |
| Cardiac failure, n (%) | 34 (5.8) | 28 (14.9) | < 0.001 |
| LVEF (%) | 65 (60-68) | 63 (58-68) | 0.016 |
| Clinical presentation | |||
| UA, n (%) | 457 (77.7) | 153 (81.4) | 0.287 |
| NSTEMI, n (%) | 82 (13.9) | 18 (9.6) | 0.119 |
| STEMI, n (%) | 49 (8.3) | 17 (9.0) | 0.762 |
| Laboratory measurements (fasting state) | |||
| TC (mg/dL) | 157.6 ± 42.5 | 156.0 ± 37.4 | 0.638 |
| LDL-C (mg/dL) | 93.8 ± 34.9 | 91.6 ± 29.5 | 0.445 |
| HDL-C (mg/dL) | 39.8 ± 9.1 | 37.9 ± 7.9 | 0.008 |
| Triglycerides (mg/dL) | 128.4 (92.1–176.2) | 145.2 (97.4–201.9) | 0.039 |
| FPG (mg/dL) | 123.8 (109.9–147.2) | 138.5 (114.2–169.4) | < 0.001 |
| Glycosylated haemoglobin (%) | 7.2 (6.6–8.1) | 7.3 (6.8–8.2) | 0.140 |
| TyG index | 9.02 ± 0.57 | 9.21 ± 0.53 | < 0.001 |
| TyG index tertiles | < 0.001 | ||
| T1, n (%) | 217 (36.9) | 40 (21.3) | – |
| T2, n (%) | 194 (33.0) | 66 (35.1) | – |
| T3, n (%) | 177 (30.1) | 82 (43.6) | – |
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, CHD coronary heart disease, MI myocardial infarction, PCI percutaneous coronary intervention, CVA cerebrovascular accident, PAD peripheral artery disease, CKD chronic kidney disease, UA unstable angina, NSTEMI non ST-segment elevation myocardial infarction, STEMI ST-segment elevation myocardial infarction, TC total cholesterol, LDL-C low-density lipoprotein-cholesterol, HDL-C high-density lipoprotein-cholesterol, FPG fasting plasma glucose, TyG triglyceride glucose