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. Author manuscript; available in PMC: 2020 Mar 10.
Published in final edited form as: J Proteome Res. 2020 Feb 7;19(2):744–755. doi: 10.1021/acs.jproteome.9b00622

Figure 6. Co-expression of homologous S100A proteins with either GPR37L1 or GPR37 also leads to secretion.

Figure 6.

To explore whether GPR37- or GPR37L1-mediated secretion was specific only to S100A5 or general for other S100A protein family members, we examined whether co-expression of either GPR37 or GPR37L1 with S100A4 or S100A10 in HEK293T cells might lead to secretion of these proteins. (A) S100A4 co-expression with either receptor resulted in detectable secretion. (B) In contrast, S100A10 secretion was not observed upon co-expression with either receptor. The positive control shown here was a media sample containing secreted S100A5.