| Methods |
Randomised controlled cross‐over trial. |
| Participants |
19 participants (11 females, 8 males) with FH, mean age 51 +/‐ 10yrs. |
| Interventions |
3 x 8 weeks periods (high fat, low fat, high fat verses low fat, high fat, low fat). Maintained on lipid lowering medication (simvastatin) throughout all arms of trial. Low fat diet = 27% energy from total fat, 8% energy from saturated fat, high fat diet = 38% energy from total fat, 14% energy from saturated fat. |
| Outcomes |
Total & HDL cholesterol, triglycerides and apolipoprotein A1 & B. |
| Notes |
NB. short‐term outcomes only will be assessed. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Stated 'randomised' but method not described. |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Not discussed. |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Unclear if an intention‐to‐treat analysis was carried out |
| Selective reporting (reporting bias) |
Low risk |
Selective reporting of outcomes was not found |
