| Methods |
Randomised controlled cross‐over trial. |
| Participants |
14 children (7 females, 7 males) with heterozygous FH, mean age 9.1 +/‐ 1.1 years. |
| Interventions |
Rapeseed oil margarine with or without sitostanol ester for 6 weeks in addition to low fat, low cholesterol diet. |
| Outcomes |
Total, VLDL, HDL & LDL cholesterol, phospholipids & triglycerides & apolipoprotein E. |
| Notes |
NB. Short‐term outcomes only will be assessed. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Stated 'randomised' but method not described. |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Described as double‐blind, but not stated who was blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Intention‐to‐treat analysis was considered adequate. |
| Selective reporting (reporting bias) |
Low risk |
All the outcomes stated in methods were reported |
